The frequent phlebotomies, and blood remaining in the dialysis tubing, contribute to iron loss. This can arise from an increased rate of blood loss during dialysis. ![]() In addition, CKD patients have an absolute iron deficiency. ![]() This is due to the fact that the ability of the body to secrete iron is negligible. The regulation of iron is done mainly by adjusting absorption. As iron has an essential role in both energy metabolism and damaging potential, its absorption, transfer, and metabolism are tightly regulated. However, due to its ability to receive and transfer electrons, iron can cause severe oxidative stress and tissue damage. Due to its unique ability to act both as an electron donor and as an electron acceptor, iron plays an imperative part in cellular respiration as well as oxygen transport and storage. Iron is a vital element in human metabolism. Pathophysiology Of Iron Metabolism In Chronic Kidney Disease Chemotherapy and radiation are two such treatments. In addition to the conditions and diseases themselves, the treatment of those diseases often causes low levels, as well. ![]() These disorders leave bone marrow unable to produce red blood cells fast enough, leading to a severe shortage. Serious blood disorders, such as some cancers, can lead to low hemoglobin levels. What Actually Can Be Causing Your Low Hemoglobin Level?
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